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When GIR was plotted as a function of lispro plasma concentrations, the sequential response-concentration relationship depicted a counterclockwise hysteresis for both healthy subjects and subjects with type 2 diabetes Fig. In Moncton 2 massage subjects receiving 10 units of insulin, an initial GIR response of 2. In obese subjects with type 2 diabetes, after a unit injection, much greater concentrations of insulin were required to produce even a minimal effect e. The response later increased abruptly to attain GIRmax when plasma concentrations of insulin were already dropping; once GIRmax was attained, the response decreased linearly with insulin plasma concentrations.

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